科氏葡萄球菌可导致Weber-Christian病患者多发性脑脓肿

• 作 者: Yamashita S Yonemura K Sugimoto R. 高中宝
• 机 构: Department of Neurology Columbia University BB-320D 650 West 168th Street New York NY 10032 United
• 出 处: 世界核心医学期刊文摘(神经病学分册)
• 发表日期: 2006年03期
• 关键词: 多发性脑脓肿 科氏葡萄球菌 Weber 皮下脂肪组织 机会致病菌 炎性结节 病因学 免疫学 发病机制

We report a patient with multiple brain abscesses due to Staphylococcus cohnii. While these brain abscesses markedly responded to the antibiotics, this patient was subsequently suffered from subcutaneous inflammatory nodules in the adipose tissue, which diagnosed him as having Weber-Christian disease (WCD). This is the first report that subcutaneous inflammatory nodules in the adipose tissue, which lead the diagnosis of WCD, followed multiple brain abscesses. To our knowledge, S. cohnii has not yet been reported to cause multiple brain abscesses in humans. Although the etiology of WCD is unknown, an immune mechanism has been implicated in the pathogenesis. Therefore, we should notice that patients with WCD could be immunocompromised hosts with a higher risk to suffer from severe opportunistic infections.

We report a patient with multiple brain abscesses due to Staphylococcus cohnii. While these brain abscesses markedly responded to the antibiotics, this patient had had suffered from subcutaneous inflammatory nodules in the adipose tissue, which diagnosed him as having Weber-Christian disease (WCD). To the knowledge, S. cohnii has not yet been reported to cause multiple brain abscesses in humans. Although the etiology of WCD is unknown, an immune mechanism has been implicated in the pathogenesis. We should notice that patients with WCD could be immunocompromised hosts with a higher risk to suffer from severe opportunistic infections.