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模拟酶,或称人工酶,是一类利用有机化学方法合成的比天然酶简单的非蛋白质分子。随着纳米科学和超分子技术的发展,构筑具有生物催化功能的超分子模拟酶材料已经越来越成为科学研究和应用开发领域的热点。肽组装凝胶是以多肽为基本单元,在非共价力驱动下形成的一种新型超分子组装体,相比其他功能性材料,肽凝胶的结构及生物化学性质更接近天然酶,分子本身更利于修饰改造,且生物相容性好,这些特点令其在模拟酶方面具有独特优势。本文总结了近几年肽组装凝胶模拟酶在催化水解反应、Aldol反应和氧化还原反应中的最新研究进展,探讨了肽组装程度、微观结构、超分子结构、活性中心微环境以及p H对模拟酶活性的影响,介绍了肽凝胶模拟酶的应用领域,并对目前肽组装凝胶模拟酶研究中存在的问题与发展方向进行了分析和展望。
Mimetic enzymes, or artificial enzymes, are a class of simple non-protein molecules that are synthesized using organic chemistry than native enzymes. With the development of nanoscience and supramolecular technology, building a supramolecular mimic enzyme material with biocatalysis has become a hot spot in the field of scientific research and applied research. Peptide assembly gel is a new type of supramolecular assembly driven by non-covalent forces based on polypeptide. Compared with other functional materials, the structure and biochemical properties of peptide gel are much closer to that of natural enzyme. Itself more conducive to modification and modification, and good biocompatibility, these features make it has a unique advantage in the simulation enzyme. This review summarizes the latest research progress of gel-mimic enzymes in peptide assembly in catalytic hydrolysis, Aldol and redox reactions in recent years. The degree of peptide assembly, microstructure, supramolecular structure, active site microenvironment and p H This paper introduced the application field of peptide gel mimic enzyme, and analyzed and prospected the existing problems in the study of gel mimic enzyme in peptide assembly.