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采用高脂血症大鼠脑内注血模型 ,比较运用逐瘀化痰汤、三生饮、抵当汤三方对注血后脑组织中自由基衍生物丙二醛 (MDA) ,Ca2 +、Fe2 +、脑含水率的效应。结果表明 ,自由基清除作用 ,三生饮优于逐瘀化痰汤、抵当汤 ;Ca2 +拮抗及降低脑含水率作用 ,逐瘀化痰汤优于抵当汤、三生饮 ,均有显著性差异 (P <0 0 5)。给药组Fe2 +升高 ,是活血化瘀药物加速血肿中红细胞破坏、促进血肿吸收的效应 ,无加速自由基反应证据。说明活血化瘀、祛痰利水、益气固脱方药对脑出血后脑损伤具有自由基清除剂及Ca2 +拮抗剂样作用
Intracerebral blood injection model of hyperlipidemic rats was used to compare the content of free radical derivatives malondialdehyde (MDA), Ca2 +, Fe2 + in the brain after injection of Zhuyu Huayu Decoction, Sanshengyin and Zhidangtang. The effect of brain moisture content. The results showed that Sanshengyin was superior to Zhuyu Huayu Decoction and Zhidang Decoction in free radical scavenging effect; Ca2 + antagonism and brain water content decreased; Zhuyu Huayu Decoction was better than Ladangtang and Sanshengyin. Difference (P < 0 0 5). The increase of Fe2 + in the administration group is the effect of the blood circulation and stasis drug in accelerating the destruction of red blood cells and promoting the absorption of hematoma in the hematoma without the evidence of accelerated free radical reaction. Explaining that Activating Blood Circulation to Remove Phlegm, Removing Blood Stasis from Water, Explaining Decoction of Yiqi Solid Decoction Has Free Radical Scavengers and Ca2+ Antagonist-like Effects on Brain Injury After Intracerebral Hemorrhage