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长期以来,人们就提出常用的镇痛药和肌松药可引起组胺释放,而致血流动力学改变。近年来,由于分析方法的改进,能够系统地测定血浆组胺水平,并相应地研制出许多H_1和H_2受体阻滞药,对药物诱发的组胺释放有了新的认识。临床研究作者为了验证肌松药和麻醉性镇痛药诱发组胺释放,研究过给予不同结构、作用时间和代谢的药物后血浆组胺水平变化。最近,对21例矫形手术病人测定了静脉推注不同剂
For a long time, people put forward commonly used analgesics and muscle relaxants can cause histamine release, resulting in hemodynamic changes. In recent years, due to the improvement of analytical methods, plasma histamine levels can be systematically determined and many H_ 1 and H_ 2 blockers have been developed accordingly, which have gained new understanding on drug-induced histamine release. In order to validate the histamine release induced by muscle relaxants and narcotic analgesics, the authors of the clinical study investigated the changes in plasma histamine levels after administration of different structures, duration of action, and metabolic drugs. Recently, 21 patients with orthopedic surgery were tested for different doses of intravenous bolus