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生物膜上类脂分子具有适应多种相的能力,膜类脂除主要形成脂双层结构外,在一定条件下,还能形成非双层类脂结构,其中包括六角形(H_(11))结构,这种现象称为膜类脂的多形性。这种六角形结构(H_(11))与生物膜的某些生理功能有关,如细胞融合、跨膜运送等等。影响生物膜上类脂分子从脂双层转变为六角形(H_(11))结构的因素很多,如温度、类脂组成、pH、二价阳离子以及药物等。本文用~(31)P-NMR(核磁共振波谱)技术,研究中药有效成份山莨菪碱对卵黄磷脂酰乙醇胺形成六角形(H_(11))的影响,山莨菪碱可促进卵黄磷脂酰乙醇胺脂质体从脂双层向六角形(H_(11))结构转变。
Biofilm lipid molecules have the ability to adapt to a variety of phases, membrane lipid in addition to the main formation of lipid bilayer structure, under certain conditions, but also the formation of non-bilayer lipid structure, including hexagonal (H_ (11) ) Structure, this phenomenon is called membrane lipid polymorphism. This hexagonal structure (H_ (11)) is associated with certain physiological functions of biofilms such as cell fusion, transmembrane transport and the like. There are many factors that affect the structure of the lipid molecules on the biomembrane from lipid bilayer to hexagonal (H_ (11)), such as temperature, lipid composition, pH, divalent cations and drugs. In this paper, ~ (31) P-NMR (nuclear magnetic resonance spectroscopy) technique was used to study the effect of Anisodamine, a traditional Chinese medicine, on the hexagonal (H_ (11)) formation of yolk phosphatidylethanolamine. Anisodamine can promote the growth of yolk phosphatidylethanolamine The plastid transition from lipid bilayer to hexagonal (H_ (11)) structure.