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目的：观察胃癌细胞内转化生长因子（ＴＧＦ）β的表达情况，探讨胃癌发展过程中ＴＧＦβ的可能作用。方法：４２例经胃镜活检、病理检查证实为胃癌。４４例浅表性胃炎的活检组织，采用免疫细胞化学方法—ＳＰ法显示ＴＧＦβ１及β２，其表达强度采用等级表示（由弱到强依次为－、±、＋、＋＋、＋＋＋）。结果：在４２例胃癌患者，ＴＧＦβ１无１例强阳性（＋＋＋），中度阳性（＋＋）１例，低度阳性（＋）１０例，可疑阳性（±）３例，阴性（－）２８例，阳性率为２６．２％。ＴＧＦβ２强阳性（＋＋＋）５例，中度阳性（＋＋）１６例，低度阳性（＋）１３例，可疑阳性（±）２例，阴性（－）６例；阳性率为８１．０％。４４例浅表性胃炎患者，ＴＧＦβ１无１例阳性（＋～＋＋＋），可疑阳性（±）４例，阴性（－）４０例。ＴＧＦβ２无１例中度阳性及强阳性（＋＋～＋＋＋），低度阳性（＋）１０例，可疑阳性（±）１例，阴性（－）３３例；阳性率为２２．７％。胃癌患者的ＴＧＦβ１、β２阳性率均明显高于浅表性胃炎，ＴＧＦβ２的阳性率在胃癌更高于ＴＧＦβ１。结论：ＴＧＦβ１，尤其是ＴＧＦβ２表达的增强是胃癌恶性演变的一个标志。
Objective: To observe the expression of transforming growth factor (TGF)β in gastric cancer cells and to explore the possible role of TGFβ in the development of gastric cancer. Methods: Forty-two cases of gastric cancer were confirmed by gastroscope biopsy and pathological examination. In 44 cases of superficial gastritis biopsies, TGFβ1 and β2 were detected by immunocytochemical method-SP method, and the expression intensity was expressed in grades (weak-strong, followed by -, ±, +, ++, +++). Results: In 42 patients with gastric cancer, there was no strong positive (+++), moderate positive (++) in 1 case, low positive (+) in 10 cases, suspicious positive (±) in 3 cases, and negative (-) in 28 cases. The positive rate was 26.2%. TGFβ2 was strongly positive (+++) in 5 patients, moderately positive (++) in 16 patients, low-positive (+) in 13 patients, suspicious positive (±) in 2 patients, and negative (-) in 6 patients; the positive rate was 81.0%. In 44 patients with superficial gastritis, there was no positive TGFβ1 (+～+++), four suspected positive (±), and negative (-) 40 patients. There was no moderate positive and strong positive TGFβ2 (++～+++), low positive (+) 10 patients, suspicious positive (±) 1 patient, and negative (−) 33 patients; the positive rate was 22.7%. The positive rates of TGFβ1 and β2 in patients with gastric cancer were significantly higher than those in superficial gastritis, and the positive rate of TGFβ2 was higher in gastric cancer than in TGFβ1. CONCLUSIONS: The increased expression of TGFβ1, especially TGFβ2, is a hallmark of the malignant evolution of gastric cancer.