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基于N-溴代丁二酰亚胺可与盐酸雷尼替丁发生氧化还原反应,剩余的N-溴代丁二酰亚胺能氧化亚甲基蓝,β-环糊精对未参加反应的亚甲基蓝具有荧光增强作用,可使其荧光增强近2倍,通过测定亚甲基蓝的荧光强度间接测定盐酸雷尼替丁的含量,建立了测定盐酸雷尼替丁荧光新方法,体系的最大激发波长为647 nm,最大发射波长为683 nm,线性范围为0.05~1.55 mg/L,检出限为7μg/L,相对标准偏差为0.2%。方法已用于实际样品的测定。
Based on N-bromosuccinimide with ranitidine hydrochloride redox reaction occurs, the remaining N-bromosuccinimide can oxidize methylene blue, β-cyclodextrin not participating in the reaction of methylene blue fluorescence The fluorescence intensity of ranitidine hydrochloride was measured by indirect determination of the concentration of ranitidine hydrochloride. A new fluorescence spectrophotometry was established for the determination of ranitidine hydrochloride. The maximum excitation wavelength of the system was 647 nm, the maximum The emission wavelength was 683 nm, the linear range was 0.05-1.55 mg / L, the detection limit was 7 μg / L and the relative standard deviation was 0.2%. The method has been used to determine the actual sample.