论文部分内容阅读
钙拮抗剂尼伐地平(Nilvadipine)与硝苯啶相比,其血管扩张作用强,对心肌的作用弱,血管选择性高,持效时间长,且一日2次给药即可。试用于10例原发性高血压患者口服本品一日2次,每次2mg或4mg,共16周,其降压效果显著的有7例,中等降低的1例,稍降低的1例,不变的1例。给药2周后平均血压降低,4周后明显降低。脉搏数无明显变化,未发现副作用及临床检查值异常。此外,对肾素、血管紧张素、醛甾酮亦无影响。另10例原发性高血压患者1次口服给药4mg,30分钟后出现降压效果,120分钟
Compared with nifedipine, Nilvadipine, a calcium antagonist, has a strong vasodilator effect, a weak myocardial effect, high vascular selectivity, and a long duration of action, and can be administered twice a day. Trial of 10 patients with essential hypertension oral administration of this product 2mg or 4mg, each for a total of 16 weeks, the antihypertensive effect was significantly in 7 cases, moderately reduced in 1 case, slightly lower in 1 case, The same one case. After 2 weeks of administration, the average blood pressure decreased significantly after 4 weeks. No significant changes in pulse rate, no side effects and clinical examination found abnormalities. In addition, no effect on renin, angiotensin, aldosterone. The other 10 cases of primary hypertension in patients with oral administration of 4mg, 30 minutes after the antihypertensive effect, 120 minutes