论文部分内容阅读
异名 Kelnac 化学名 (2 E,6 Z,10 E)-7-羟甲基-3,11,15-三甲基-2,6,10,14-十六碳四烯醇药效分类抗溃疡药开发单位 (日)三共株式会社研究所上市厂商 (日)三共株式会社1986年11月药理本品为从泰国大戟科巴豆属植物Croton sulblyratus Kurz的茎叶中提出的有效成分,是防御因子增强型抗溃疡药。对多种实验性溃疡,如由应激、利血平、阿司匹林、消炎痛、半胱胺、醋酸、幽门结扎、幽门结扎加阿司匹林所致的鼠和狗的溃疡,都有抑制与促进溃疡愈合的作用。在动物或人体均显示能减轻由阿司匹林引起的胃粘膜电位差降低及前列腺素PGE_2及PGI_2的减少,能增
Synonyms Kelnac Chemical name (2 E, 6 Z, 10 E) -7-hydroxymethyl-3,11,15-trimethyl-2,6,10,14-hexadecyl tetraenol Pharmacodynamic classification of resistance Research Institute of Sankyo Co., Ltd. Research Institute of Sankyo Co., Ltd. Sankyo Co., Ltd. Nov. 1986 Pharmacology This product is the active ingredient proposed in stems and leaves of Croton sullyratus Kurz from the genus Euphorbia, Factor-enhanced anti-ulcer drugs. For many experimental ulcers, such as ulcers of rats and dogs caused by stress, reserpine, aspirin, indomethacin, cysteamine, acetic acid, pylorus ligation, pyloric ligation plus aspirin, there is inhibition and promotion of ulcer healing Role. In animals or humans, it has been shown to reduce the decrease in gastric mucosal potential caused by aspirin and decrease in prostaglandin PGE 2 and PGI 2