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目的观察急性有机磷农药中毒中间型综合征的临床特点探讨治疗方法。方法将符合标准的AOPP患者中间型综合征42例,随机分为治疗组与对照组,在常规对症治疗,辅助呼吸机、氯解磷定治疗的基础上治疗组使用长托宁。对照组使用阿托品。监测血胆碱酯酶活力、监测肌力、生命体征、血气分析、电解质、血氧饱和度等。结果治疗组22例,总有效率18/22(81.8%),死亡4例死亡率4/22(18.2%),对照组20例总有效率14/20(70%),死亡6例,死亡率6/20(30%)。其它监测指标治疗组与对照组有差异统计学意义,P>0.05。结论长托宁在治疗急性有机磷中毒并中间型综合征患者明显优于阿托品。
Objective To observe the clinical features of acute organophosphorus pesticide poisoning syndromes and discuss the treatment methods. Methods Forty-two AOPP patients with intermediate syndrome were randomly divided into treatment group and control group. On the basis of conventional symptomatic treatment, ventilator assisted therapy and chlorophenanthroline treatment, the treatment group was given penehyclidine hydrochloride. The control group used atropine. Monitoring of blood cholinesterase activity, monitoring of muscle strength, vital signs, blood gas analysis, electrolytes, oxygen saturation and so on. Results Twenty-two patients in the treatment group had a total effective rate of 18/22 (81.8%), 4 deaths were 4/22 (18.2%), 20 (70%) patients were in the control group, 6 died and 6 died Rate 6/20 (30%). Other indicators of the treatment group and the control group were statistically significant, P> 0.05. Conclusions Penehyclidine is superior to atropine in the treatment of acute organophosphate poisoning and in patients with intermediate syndrome.