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目的观察汉防已甲素气雾剂治疗支气管哮喘和喘息型慢性支气管炎的临床疗效。方法438例患者治疗前详细记录病史,在治疗前和治疗后1、3、5、10、20min各记录喘息、程度及哮鸣音分布情况,治疗前和治疗后10、20min各记录呼吸次数和心率。结果即时平喘疗效与愈喘气雾组比较,总有效率和显效以上率无明显差异(P>0.05),与空白对照气雾剂组比较,则有极显著性差异(P<0.001);肺功能疗效的VC、FEV1、MMEF、FEV75~85%各均值治后较治前均略有升高,但统计学处理无明显差异(P>0.05);起效和维持时间1~2h以上,少数病例可维持24h。结论汉防已甲素气雾剂的平喘效果是确切的并有肺通气功能的作用,而肺功能变化不明显。
Objective To observe the clinical efficacy of anti-tuberculosis aerosol anti-bronchial asthma and asthmatic chronic bronchitis. Methods 438 patients were recorded before treatment history, before and after treatment 1, 3, 5, 10, 20min recorded wheezing, degree and wheeze distribution, before and after treatment 10,20min the number of records of respiratory and Heart rate. Results Compared with the control group, there was no significant difference in the total effective rate and the effective rate (P> 0.05) between the asthma group and the asthmatic aerosol group. There was a significant difference (P <0.001) The functional curative effect of VC, FEV1, MMEF, FEV75 ~ 85% of the mean after treatment were slightly higher than before treatment, but no significant difference between the statistical analysis (P> 0.05); onset and maintenance of more than 1 ~ 2h, a few Case can be maintained 24h. Conclusion The antiasthmatic effect of hafluofen-1 aerosol is definite and has the function of pulmonary ventilation, while the changes of pulmonary function are not obvious.