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采用微管吸吮技术观察了体外培养肺血管内皮细胞及新鲜分离的红细胞在用青心酮处理后生物力学特性的变化。与未用药组比较 ,在加用青心酮 30 m in后 ,中、大剂量组内皮细胞弹性系数 K1 和 K2 增大 (P<0 .0 5 ) ,粘性系数 μ变化不大 ;红细胞表观变形指数和最大变形值也明显增加 (P<0 .0 5或 P<0 .0 1)。提示青心酮可以增加肺血管内皮细胞弹性 ,并使红细胞变形能力明显增强 ,这可能是青心酮改善血液循环的生物力学机制。
The microtubule sucking technique was used to observe the changes of biomechanical properties of cultured pulmonary vascular endothelial cells and freshly isolated erythrocytes after treatment with monofloxacin. Compared with the untreated group, the elastic coefficient K1 and K2 of middle and large dose groups increased (P <0. 05) and viscous coefficient μ changed little after adding monomycinone for 30 minutes, while erythrocyte apparent Deformation index and maximum deformation values also increased significantly (P <0.05 or P <0.01). These results suggest that CYP can increase the elasticity of pulmonary vascular endothelial cells and enhance the deformability of erythrocytes, which may be the biomechanical mechanism of CYP in improving blood circulation.