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本文观察15例心内直视手术病人麻醉前后和体外循环前后血浆心钠素(ANF)、肾素(PRA)、血管紧张素Ⅱ(AⅡ)和醛固酮(Ald)水平的动态变化.结果示:适度芬太尼和安氟醚麻醉,手术和体外循环不影响先心患者血浆ANF水平.风心病人基础ANF水平高,麻醉对其无明显影响,手术中进一步升高,体外循环后显著下降(P<0.01).麻醉对PRA、AⅡ和Ald影响不大.体外循环对PRA无明显影响;但使风心患者术中升高的AⅡ恢复,及降低的Ald显著升高(P<0.01).ANF与AⅡ呈直线正相关,r=0.630(P<0.05).
In this paper, we observed the dynamic changes of plasma ANP, AII and Ald before and after anesthesia and cardiopulmonary bypass in 15 patients undergoing open heart surgery.The results showed that: Moderate fentanyl and enflurane anesthesia, surgery and cardiopulmonary bypass does not affect the level of plasma ANF in patients with congenital heart disease patients with high levels of basic ANF, anesthesia had no significant effect on surgery further increased, decreased significantly after cardiopulmonary bypass P <0.01) .Anesthesia had little effect on PRA, AII and Ald, while CPB had no significant effect on PRA, but recovery of AⅡ in patients with rheumatic heart disease and decrease of Ald were significantly increased (P <0.01). There was a linear positive correlation between ANF and AII, r = 0.630 (P <0.05).