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妇科恶性肿瘤是影响女性健康的主要威胁。相关研究发现,肿瘤转移抑制基因1(metastasis suppressor1,MTSS1),在宫颈组织中从CIN I到宫颈癌,随病变程度增加表达阳性率增加;而在卵巢癌中MTSS1表达的下调与卵巢癌细胞的侵袭性密切相关,其过表达可抑制卵巢癌侵袭性,另有研究发现血细胞中MTSS1表达的下调标志其不良预后;其他妇科恶性肿瘤与MTSS1表达相关性仍需进一步研究。在其他器官恶性肿瘤中,MTSS1呈现为特异性表达。MTSS1在妇科恶性肿瘤中的表达差异可能会对临床诊疗、判断预后以及复诊评估起到指导作用。
Gynecologic cancer is a major threat to women’s health. Related studies have found that the metastasis suppressor 1 (MTSS1) in cervical tissue from CIN I to cervical cancer increased with the degree of lesion increased the positive rate; while in ovarian cancer MTSS1 expression and ovarian cancer cells Invasion is closely related to its over-expression of ovarian cancer can inhibit the invasiveness of another study found that the decline of MTSS1 expression in blood cells marked its poor prognosis; other gynecologic malignancies and MTSS1 expression remains to be further studied. In other organ malignancies, MTSS1 appears to be specifically expressed. The difference of MTSS1 expression in gynecological malignancies may play a guiding role in clinical diagnosis, prognosis and follow-up evaluation.