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肾脏疾病生存质量指导(KDOQI)制定了对慢性肾脏病(CKD)各期的甲状旁腺素(PTH)治疗目标值,建议应常规检测CKD患者的血清PTH水平,并维持在CKD各期相应的目标值范围内。PTH检测结果直接决定着慢性肾脏病患者治疗方案的制定。检测PTH主要采用两种方法,第一代的放射免疫测定法,第二、三代的双抗体识别法。目前在临床应用中广泛使用的是第二、三代检测方法,而检测方法的选择、检测的标准化、检测值的校正是目前PTH检测存在的主要问题。
Kidney Disease Quality of Life Guidelines (KDOQI) set goals for the treatment of parathyroid hormone (PTH) in various stages of CKD and suggest that serum PTH levels should be routinely measured in CKD patients and maintained at the corresponding Within target range. PTH test results directly determine the formulation of treatment of patients with chronic kidney disease. There are two main methods for detecting PTH, the first generation of radioimmunoassay and the second and third generation of diabodies. Currently widely used in clinical applications is the second and third generation detection methods, and the selection of detection methods, the standardization of detection, the correction of the detection value is the main problem of PTH detection.