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本文研究杀虫剂六六六(HCB)的慢性毒性,实验结果证明长期经口给药后,HCB 对地鼠有致癌性。实验采用六周龄的叙利亚金色地鼠作终生试验。动物随意进食含有50、100、200ppmHCB 的饲料,摄入量分别为4、8、16mg/kg/天。HCB 纯度在99.5%以上(BDH、英格兰)。实验结果:50周龄时,71%的实验动物存活,与对照组相似。70周以后,200ppm 组雌雄动物的生命较对照组短,雄性动物的体重显著降低。各剂量组肿瘤发病率的累计资料见下表。
In this paper, the chronic toxicity of pesticide Hexachlorohexahydrate (HCB) was studied. The experimental results show that HCB is carcinogenic to gophers after long-term oral administration. Six-week-old Syrian golden hamster was used for the lifetime test. Animals randomly fed diets containing 50, 100, 200 ppmHCB at 4, 8 and 16 mg / kg / day, respectively. HCB purity is above 99.5% (BDH, England). Experimental Results: At the age of 50 weeks, 71% of the experimental animals survived, similar to the control group. After 70 weeks, the male and female animal of 200ppm group had shorter life span than control group, and the weight of male animals decreased significantly. The cumulative incidence of each dose of tumor data in the table below.