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目的 :探讨耳针和六味地黄加味对去势雌鼠骨质疏松症的影响。方法 :通过切除 6月龄雌鼠双侧卵巢建立骨质疏松症的动物模型。大鼠被随机分为 6组 ,各组分别经耳针、六味地黄加味和苯甲酸雌二醇的 3个月治疗后将大鼠处死、取血 ,用放免法测定血清 E2 ,BGP,IL-1,IL-6和骨 BMD,BMC含量。结果 :耳针、六味地黄加味和苯甲酸雌二醇的治疗均能提高 E2 ,BMD,BMC的水平 ,同时能抑制 BGP,IL-1,IL-6的分泌。结论 :耳针、六味地黄加味对骨质疏松症的骨形成和骨吸收有调节作用 ,能早期预防和治疗骨质疏松症 ,是值得进一步研究的新方法。
Objective : To investigate the effects of auricular acupuncture and Liuweidihuang addition on osteoporosis in ovariectomized female rats. METHODS: An animal model of osteoporosis was established by excising bilateral ovaries from 6-month old females. Rats were randomly divided into 6 groups. Each group was treated with auricular acupuncture, Liu Wei Di Huang Jia Wei and estradiol benzoate for 3 months. The rats were sacrificed and blood was taken. Serum E2, BGP, IL- were determined by radioimmunoassay. 1, IL-6 and bone BMD, BMC content. Results: The treatment of auricular acupuncture, Liu Wei Di Huang Jia Wei and estradiol benzoate can increase the levels of E2, BMD and BMC, and inhibit the secretion of BGP, IL-1 and IL-6. Conclusion : The auricular acupuncture and Liuwei Dihuang have modulating effect on bone formation and bone resorption of osteoporosis and can prevent and treat osteoporosis early. It is a new method worthy of further study.