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作者报告应用单克隆抗体CT-2和补体清除供者骨髓中T淋巴细胞,对16例先天性T淋巴细胞缺陷综合征患者共施行20次骨髓移植(BMT)。供者骨髓除1例取自患者母亲外,其余均取自父亲。供、受者骨髓单倍体相同。移植前的预处理方案为白消安、阿糖胞苷和环磷酰胺或阿糖胞苷、环磷酰胺加1365CGY全身照射。结果:8/16例存活且状况良好,8/16例死于移植中的感染。移植后无1例接受预防移植物抗宿主病(GVHD)治疗,仅1例发生严重的急性GVHD,另7例为轻度GVHD,未发生慢性GVHD。移植后受者获得T、B细胞功能持久性重建。作者认为,用单克隆抗体和兔补体净化所得到的无T细胞的单倍体相同的
The authors report the use of monoclonal antibody CT-2 and complement to clear the donor’s bone marrow T-lymphocytes. Sixteen patients with congenital T-cell deficiency syndrome underwent 20 bone marrow transplantation (BMT). In addition to donor bone marrow in 1 patient taken from the mother, the rest were taken from his father. For the recipient bone marrow haploidentical same. Pretreatment programs for pretreatment busulfan, cytarabine and cyclophosphamide or cytarabine, cyclophosphamide plus 1365CGY whole body irradiation. Results: 8/16 survived in good condition and 8 of 16 died of transplanted infection. None of the patients underwent graft-versus-host disease (GVHD) after transplantation. Only one developed severe acute GVHD and the other seven had mild GVHD without chronic GVHD. After transplantation recipients of T, B cell function of permanent reconstruction. In the authors’ opinion, the same T cell-free haplotypes obtained by the purification of monoclonal antibodies and rabbit complement