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目的比较螺内酯与美托洛尔对冠心病患者心室重构及QT离散度的影响。方法冠心病患者98例,随机分成对照组和治疗组,每组49例。对照组采用美托洛尔治疗,治疗组采用螺内酯治疗,观察两组患者治疗前后心室重构及QT离散度。结果治疗后,两组心室重构状况较治疗前明显降低,且治疗组较对照组更低(P<0.05);两组QT离散度较治疗前明显缩小,且治疗组较对照组更明显(P<0.05)。结论采用螺内酯治疗冠心病效果明显,能有效的逆转心室重构状况,降低QT离散度,可推广应用。
Objective To compare the effects of spironolactone and metoprolol on ventricular remodeling and QT dispersion in patients with coronary heart disease. Methods 98 patients with coronary heart disease were randomly divided into control group and treatment group, 49 cases in each group. The control group was treated with metoprolol, the treatment group was treated with spironolactone, and the ventricular remodeling and QT dispersion were observed before and after treatment in both groups. Results After treatment, the ventricular remodeling in both groups was significantly lower than that before treatment, and the treatment group was lower than the control group (P <0.05). The QT dispersion of the two groups was significantly reduced compared with that before treatment, and the treatment group was more obvious than the control group P <0.05). Conclusion Spironolactone treatment of coronary heart disease effect is obvious, can effectively reverse the ventricular remodeling, reduce QT dispersion, can be extended.