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目的研究孟鲁司特钠联合沙美特罗替卡松治疗小儿支气管哮喘的临床效果。方法 134例支气管哮喘的患儿,随机将其分成对照组和治疗组,每组67例。对照组患儿采用常规对症治疗加沙美特罗替卡松治疗,治疗组患儿在此基础上加用孟鲁司特钠联合治疗,观察两组患儿治疗效果、肺功能及不良反应情况。结果两组患儿在治疗期间均未发生与药物相关的不良反应。治疗后,治疗组患儿的总有效率明显高于对照组,差异有统计学意义(P<0.05);治疗组患儿的肺功能情况明显优于对照组,差异均有统计学意义(P<0.05)。结论小儿支气管哮喘患儿在对症治疗基础上配合孟鲁司特钠联合沙美特罗替卡松共同治疗效果明显,能有效提高临床疗效,改善患儿肺功能,安全性较高,可临床推广应用。
Objective To study the clinical effects of montelukast sodium combined with salmeterol and fluticasone in children with bronchial asthma. Methods A total of 134 children with bronchial asthma were randomly divided into control group and treatment group, with 67 cases in each group. Children in the control group were treated with gatifloxacin and ticalatopril in the conventional symptomatic treatment. The children in the treatment group were treated with montelukast sodium on the basis of the above treatment. The therapeutic effect, lung function and adverse reactions in both groups were observed. Results The two groups of children during the treatment did not occur with drug-related adverse reactions. After treatment, the total effective rate of the treatment group was significantly higher than that of the control group, the difference was statistically significant (P <0.05); the pulmonary function of the treatment group was significantly better than the control group, the difference was statistically significant (P <0.05). Conclusion Children with bronchial asthma on the basis of symptomatic treatment with montelukast combined with salmeterol and ticlabussong common treatment effect can effectively improve the clinical efficacy and improve lung function in children with higher safety can be clinically applied .