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国内外研究已证明乙酸铜具有抗癌活性。然而，其作用机理尚未阐述清楚。用ＢＡＬＢ／ｃ小鼠，移植腹水型肝癌（ＨｅｐＡ），经口给乙酸铜水溶液（２９ｍｇ／ｋｇ），２０ｄ后取腹水癌细胞，经流式细胞光度计分析发现，给铜组癌细胞平均ＤＮＡ含量为９４．８±２．１，明显低于对照组（９７．９±２．６，Ｐ＜０．０５）；给铜组Ｇ１期癌细胞明显增多（２３．８±６．５），对照组１６．６±２．６（Ｐ＜０．０５）；给铜组癌细胞增殖指数（ＰＩ）明显降低（７５．６±６．２），对照组８３．４±２．６（Ｐ＜０．０５）；给铜组ＤＮＡ组方图中近二倍体峰比对照组明显增高，而多倍体峰明显降低或变小。认为，乙酸铜可以抑制癌细胞的ＤＮＡ合成，进而导致分裂增殖受阻。同时注意到铜有诱导癌细胞分化的迹象，有待深入研究。
Domestic and foreign studies have shown that copper acetate has anti-cancer activity. However, its mechanism of action has not been elucidated yet. Ascites hepatocellular carcinoma (HepA) was transplanted with BALB / c mice, and treated with copper acetate aqueous solution (29mg / kg) orally. The ascitic carcinoma cells were harvested after 20 days. The results of flow cytometer showed that the average DNA (94.8 ± 2.1), significantly lower than that of the control group (97.9 ± 2.6, P <0.05). The number of G1 phase cancer cells in the copper group increased significantly (23.8 ± 6.5) The control group was 16.6 ± 2.6 (P <0.05). The proliferation index (PI) of copper group was significantly lower (75.6 ± 6.2) and 83.4 ± 2.6 (P <0.05). Compared with the control group, the near diploid peak in the group of DNA to copper group was significantly increased, while the polyploid peak was significantly reduced or decreased. That copper acetate can inhibit DNA synthesis of cancer cells, which led to blocked the division of proliferation. At the same time, it is noticed that copper shows signs of cancer cell differentiation and needs further study.