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本文进行了马洛替酯软胶丸和马洛替酯片在８例健康志愿者中的药代动力学及相对生物利用度研究，采用高效液相色谱法测定血清中具有生物活性的代谢物马洛替酯的单酯的浓度。结果发现，两种剂型在体内血药浓度－时间曲线均符合一室模型。马洛替酯软胶丸的主要药代动力学参数分别为：Ｔｐｅａｋ＝２．０２±０．１８ｈ，Ｃｍａｘ＝６．８０±２．０８ｍｇ／１．Ｔｋｅ＝１．８６±０．６３ｈ，ＡＵＣ＝３９．０６±１１．５２ｍｇ·ｈ￣（－１）·Ｌ￣（－１）。其相对生物利用度为１１９．９２％。
In this paper, the pharmacokinetics and relative bioavailability of the soft capsule of marloside and maluotidil in eight healthy volunteers were studied. The metabolites of the bioactive metabolites in the serum were determined by high performance liquid chromatography The monoester concentration of aloxacin. The results showed that the two formulations in vivo plasma concentration - time curve are in line with the one-compartment model. The main pharmacokinetic parameters of the soft capsule of marloside were Tpeak = 2.02 ± 0.18h and Cmax = 6.80 ± 2.08mg / 1, respectively. Tke = 1.86 ± 0.63h, AUC = 39.06 ± 11.52mg · h ~ (-1) · L ~ (-1). Its relative bioavailability was 119.92%.