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目的探究疏血通注射液联合酒石酸美托洛尔治疗不稳定性心绞痛的临床效果。方法选取2014年2月—2017年1月收治的不稳定性心绞痛患者74例,按照随机数字表法分为对照组和观察组,各37例。对照组予以硝酸酯类药物、他汀类药物、β受体阻断剂等常规治疗,观察组在治疗组基础上予以疏血通注射液联合酒石酸美托洛尔治疗。观察两组治疗效果,对比两组治疗前后血流动力学指标及血清血清基质金属蛋白酶-9(MMP-9)、可溶性细胞间黏附分子(s ICAM-1)水平变化情况。计量资料比较采用t检验,计数资料比较采用χ~2检验,P<0.05为差异有统计学意义。结果观察组治疗总有效率97.30%(36/37)高于对照组75.68%(28/37),差异有统计学意义(P<0.05);治疗前两组血清MMP-9、s ICAM-1水平、血液流变学指标比较,差异无统计学意义(P>0.05);治疗后观察组血清MMP-9、s ICAM-1水平、纤维蛋白原、血小板聚集率及红细胞聚集指数[(23.82±3.34)μg/L、(613.71±60.54)ng/ml、(2.04±0.73)g/L、(37.51±5.62)%、(4.00±0.39)]均低于对照组[(29.85±5.32)μg/L、(693.92±68.61)ng/ml、(2.68±0.69)g/L、(44.08±6.74)%、(4.35±0.42)],差异有统计学意义(均P<0.05)。结论疏血通注射液与酒石酸美托洛尔联合治疗不稳定性心绞痛,可明显改善患者血液流变学,有效降低血清MMP-9、s ICAM-1水平,进一步提高治疗效果。
Objective To investigate the clinical effect of Shuxuetong injection combined with Metoprolol tartrate in the treatment of unstable angina pectoris. Methods Totally 74 patients with unstable angina pectoris who were admitted from February 2014 to January 2017 were divided into control group and observation group according to random number table. The control group was treated with nitrates, statins and β-blockers. The observation group was treated with Shuxuetong injection and metoprolol tartrate on the basis of the treatment group. The therapeutic effects of the two groups were observed. The changes of hemodynamics, serum matrix metalloproteinase-9 (MMP-9) and soluble intercellular adhesion molecule-s ICAM-1 were compared between the two groups before and after treatment. Measurement data were compared using t test, count data were compared using χ ~ 2 test, P <0.05 for the difference was statistically significant. Results The total effective rate of observation group was 97.30% (36/37) higher than that of control group (75.68%, 28/37), the difference was statistically significant (P <0.05) (P> 0.05). After treatment, the levels of serum MMP-9 and sICAM-1, fibrinogen, platelet aggregation and erythrocyte aggregation index [(23.82 ± (29.45 ± 5.32) μg / L, (3.34 ± 0.73) g / L, (37.51 ± 5.62)%, (4.00 ± 0.39) L, (693.92 ± 68.61) ng / ml, (2.68 ± 0.69) g / L, (44.08 ± 6.74)%, (4.35 ± 0.42)] respectively. There were significant differences between the two groups (all P <0.05). Conclusion Shuxuetong injection and metoprolol tartrate combined treatment of unstable angina pectoris can significantly improve the patient’s blood rheology, effectively reduce serum levels of MMP-9, s ICAM-1 and further improve the therapeutic effect.