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目的研究对比法舒地尔不同给药途径治疗颅内动脉瘤栓塞后脑血管痉挛的临床效果,为临床医生治疗颅内动脉瘤栓塞后脑血管痉挛提供可靠依据。方法选择行颅内动脉瘤栓塞后脑血管痉挛的患者62例,随机将其分成A、B组,每组各31例。两组均采用法舒地尔治疗,A组行静脉滴注法舒地尔,B组行动脉内注射+静脉滴注法舒地尔,观察两组患者治疗效果。结果 B组在平均解血管痉挛时间、GCS评分、GOS评分、治疗效果方面均明显优于A组,差异均有统计学意义(P<0.05)。结论对颅内动脉瘤栓塞后脑血管痉挛的患者采用动脉推注法舒地尔治疗效果更明显,能有效的提高疗效,缩短解血管痉挛时间,提高预后效果。
Objective To compare the clinical efficacy of fasudil administered by different routes of administration in treating cerebral vasospasm after intracranial aneurysm embolization and provide a reliable basis for clinicians to treat cerebral vasospasm after intracranial aneurysm embolization. Methods Sixty-two patients with cerebral vasospasm after intracranial aneurysm embolization were randomly divided into groups A and B, with 31 cases in each group. Both groups were fasudil treatment, A group of intravenous fasudil, B group intra-arterial infusion + intravenous fasudil, the treatment effect of two groups were observed. Results In group B, the average time of vasospasm, GCS score, GOS score and treatment effect were significantly better than those in group A (all P <0.05). Conclusion The treatment of cerebral artery spasm by intracranial aneurysm embolization with fasudil is more effective. It can effectively improve the curative effect, shorten the time of vasospasm and improve the prognosis.