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目的研究热毒宁针剂对肺炎支原体肺炎患儿淋巴细胞亚群及血清Th17、IL-17A的影响。方法选择2015年2月至2016年2月80例支原体肺炎患儿作为研究对象,采用随机数表法分为两组,每组40例。观察组行常规治疗联合热毒宁针剂,对照组行常规治疗。观察两组治疗效果及对患者淋巴细胞亚群和血清Th17、IL-17A等细胞因子水平的影响。结果观察组治疗总有效率为95%,对照组80%,差异有统计学意义(P<0.05)。治疗后观察组Th1和Th2分别为(18.74±4.36)%和(5.79±0.68)%,显著高于治疗前和对照组治疗后,观察组治疗后IL-17A为(10.15±1.13)pg/ml,显著低于治疗前和对照组治疗后,差异均有统计学意义(P<0.05)。结论热毒宁治疗肺炎支原体感染患儿疗效显著,可能与热毒宁抑制炎症反应和修复免疫功能有关。
Objective To study the effect of Reduining injection on lymphocyte subsets and serum Th17, IL-17A in children with Mycoplasma pneumoniae pneumonia. Methods From February 2015 to February 2016, 80 children with mycoplasma pneumonia were selected as the study subjects and divided into two groups (n = 40) with random number table. The observation group received routine treatment combined with Rendoxining injection, and the control group received routine treatment. To observe the effect of treatment and the effect of Th17, IL-17A and other cytokines in patients with lymphocyte subsets and serum. Results The total effective rate was 95% in the observation group and 80% in the control group, the difference was statistically significant (P <0.05). After treatment, the levels of Th1 and Th2 in the observation group were (18.74 ± 4.36)% and (5.79 ± 0.68)%, respectively, which were significantly higher than those before treatment and those in the control group (10.15 ± 1.13 pg / ml , Significantly lower than before treatment and control group after treatment, the difference was statistically significant (P <0.05). Conclusion Rendunning treatment of Mycoplasma pneumoniae infection in children with significant efficacy may be related to the heat toxicity rather inhibit inflammatory response and repair immune function.