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目的探讨前列地尔治疗后循环缺血的临床效果。方法将96例后循环缺血患者按照随机、自愿的原则分为对照组和研究组,每组各48例。对照组患者给予常规治疗,研究组患者在常规治疗基础上加用前列地尔,疗程均为2周。比较两组患者治疗前后美国国立卫生院神经功能缺损评分(NIHSS)及治疗效果。结果研究组患者治疗后总有效率明显高于对照组患者,差异有统计学意义(91.67%vs 75.00%,χ~2=5.636,P<0.05)。两组患者治疗后两组NIHSS均明显降低,与治疗前相比均有统计学差异(均P<0.05);治疗后研究组患者下降更为明显,与对照组相比差异均有统计学意义(P<0.05)。结论前列地尔能够明显改善后循环缺血患者的神经功能,疗效可靠,值得在临床中推广应用。
Objective To investigate the clinical effect of alprostadil on ischemic postconditioning. Methods 96 patients with posterior circulation ischemia were divided into control group and study group according to the principle of randomization and voluntariness, 48 cases in each group. Patients in the control group were given conventional treatment. Patients in the study group were treated with alprostadil on the basis of routine treatment, and the course of treatment was 2 weeks. The National Institutes of Health neurological deficit score (NIHSS) and treatment outcome were compared between the two groups before and after treatment. Results The total effective rate of the study group was significantly higher than that of the control group (91.67% vs 75.00%, χ ~ 2 = 5.636, P <0.05). After treatment, NIHSS in both groups were significantly decreased compared with those before treatment (all P <0.05); after treatment, the decline of NIHSS in the study group was more obvious, the difference was statistically significant compared with the control group (P <0.05). Conclusion Alprostadil can significantly improve the neurological function of patients with posterior circulation ischemia and has reliable curative effect and is worth popularizing in clinic.