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目的 评价奥美拉唑（ 洛赛克） 对肝源性溃疡（ＨＵ） 的疗效。方法 对２５１ 例肝硬化经胃镜检查出溃疡的４８ 例患者，予每日晨服奥美拉唑２０ｍｇ，疗程４ ～６ 周，着重观察胃镜下溃疡愈合情况，并与同期消化性溃疡（ＰＵ） 疗效对比分析。结果 ４ 周愈合率ＨＵ 组中，十二指肠溃疡（ＤＵ） 为６９ ．２％（１８／２６ 例），胃溃疡（ＧＵ） 为５２．９％ （９／１７ 例） ；ＰＵ 组中ＤＵ 与ＧＵ 均为１００％ （３１／３１ 与６／６ 例），两组比较差异有非常显著性（Ｐ＜ ０．０１）。６ 周愈合率ＨＵ 中ＤＵ 为８４ ．６％ （２２／２６），ＧＵ 为８２ ．３（１４／１７ 例） 。肝功能Ｃｈｉｌｄ Ｃ级者溃疡愈合率明显降低。结论 奥美拉唑治疗ＨＵ 疗效满意。但疗程较ＰＵ 长。ＨＵ 的愈合于Ｃ级患者较低。
Objective To evaluate the efficacy of omeprazole (Losec) on liver ulcer (HU). Methods Forty-eight patients with gastric ulcer diagnosed by liver cirrhosis were enrolled in this study. Omeprazole 20 mg was given daily for 4 to 6 weeks. The ulcer healing under the endoscopy was observed. In the same period, peptic ulcer (PU) Comparison of curative effect. Results 4 weeks healing rate HU group, duodenal ulcer (DU) was 69. 2 cases (18/26 cases) and gastric ulcer (GU) was 52.9% (9/17 cases). The DU and GU in PU group were all 100% (31/31 and 6/6 cases) The difference was significant (P <0.01). The DU healing rate was 84 in HU at 6 weeks. 6% (22/26), GU 82. 3 (14/17 cases). Child C grade liver function ulcer healing rate was significantly lower. Conclusion Omeprazole is effective in treating HU. But the treatment longer than PU. HU healing in patients with C-level lower.