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Purpose: To analyze causes of acute nonvariceal gastrointestinal bleeding (GIB) with negative digital subtraction angiography (DSA) results.Materials and methods: The clinical and follow-up data of 133 patients-recruited between February 2008 and November 2016-with acute nonvariceal GIB and negative DSA results were included in this study.DSA results,diagnoses,and clinical outcomes were recorded.Results: The DSA results were negative in all 133 patients.Of the total,55 patients (41.4％) chose to undergo surgery and 78 (58.6％) opted for conservative treatment.Within 30 days,there was no significant difference in the rebleeding or mortality rates between the two groups (P ＜.05).Of all 133 patients,76 (57.1％) had upper GIB and 57 (42.9％) had lower GIB;within 30 days,the rebleeding rate in the upper GIB group (44.7％,34/76) was significantly higher than that in the lower GIB group (26.3％,15/57).There was no significant statistical difference (P ＜.05) within 30 days in the mortality rates between the two groups.Among patients with upper GIB,26 (34.2％,26/76) opted to undergo surgery and 50 (65.8％,50/76) chose conservative treatment;within 30 days,the rebleeding rate in the group that chose surgery (61.5％,16/26) was higher than that in the conservative treatment group (36％,18/50).There was no significant difference (P ＜.05)within 30 days in the mortality rate between the two groups.Among the patients with lower GIB,29 (50.9％,29/57) chose to undergo surgery and 28 (49.1％,28/57) opted for conservative treatment.Within 30 days,the rebleeding rate in the surgery group (13.8％,4/29) was lower than that in conservative treatment group (39.3％,11/28).There was no significant difference (P ＜.05) within 30 days in the mortality rate between the two groups.Sixteen patients underwent prophylactic arterial embolization;in 6 of these,bleeding was stopped for 30 days.DSA was then repeated in these 16 patients after a median interval of 1 day,and a positive bleeding site was found in 9 of the 16.Causes of bleeding were found in 111 patients by surgery or endoscopy,whereas the causes remained unknown in 22 patients.Conclusions: Upper GIB with negative DSA results was stopped by conservative treatment,whereas lower GIB required surgery to detect the culprit bleeding site.Rare causes of GIB should be considered and appropriate management selected in a timely manner in order to detect unusual causes.