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以往人们很少把粉尘看作是一个致癌因子,在流行病调查空气污染和抽烟与肺癌的关系中提示粉尘可能是一个因素。为了解粉尘颗粒、纤维粉尘与肺癌的关系,作者检查了14名死于肺癌的病人和14具对照尸体的肺内粉尘颗粒、纤维粉尘的含量。选择肺癌病人的要求是:(1)必须通过病理检查确认为肺癌者;(2)无职业接触矿尘和其他矿尘接触史;(3)有详细的抽烟史;(4)除阻塞性肺病外,无其他肺病.对照组按年龄、性别、抽烟史和职业分类进行配对。通过形态学、电子衍射、能量色散 X-线分光器来计数、测量和鉴别粉尘颗粒和纤维粉尘。结果肺癌组平均的外源性粉尘颗粒数为525±369×10~(?)/g 肺干重,外源性纤维粉尘数为17.4±19.6×10~6/g 肺干重,而对照组平均外源性粉尘颗粒数为261±175×10~(?)/g 肺干重,外源性纤维粉尘数为4.7
In the past, dust was rarely seen as a carcinogenic factor, suggesting that dust may be a factor in the investigation of the prevalence of air pollution and smoking in relation to lung cancer. To understand the relationship between dust particles, fiber dust and lung cancer, the authors examined the lung dust particles, fiber dust content in 14 patients who died of lung cancer and 14 controls. The requirements for selecting patients with lung cancer are: (1) lung cancer must be confirmed by pathology; (2) history of occupational exposure to dust and other dusts; (3) detailed smoking history; (4) There was no other lung disease in the control group, which was matched by age, sex, smoking history and occupational classification. Dust particles and fiber dust were measured and identified by morphological, electron diffraction, energy dispersive X-ray spectroscopy. Results The mean number of exogenous dust particles in lung cancer group was 525 ± 369 × 10 ~ (?) / G and the dry weight of exogenous fiber was 17.4 ± 19.6 × 10 ~ 6 / g, while the control group The average number of exogenous dust particles was 261 ± 175 × 10 ~ (?) / G, and the exogenous fiber dust was 4.7