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目的:探讨莫西沙星药品不良反应(ADR)发生特点,为临床用药安全提供依据。方法:对我院2007～2009年上报北京市药品不良反应监测中心的31例莫西沙星ADR报告进行统计分析。结果:莫西沙星ADR发生例数逐年增高,呈上升趋势。ADR损害系统/器官构成比高低依次为过敏反应(41.9%)、神经系统(19.4%)、心血管系统(16.1%)、消化系统(6.4%)等。主要临床表现为皮疹、视觉异常、幻觉、抽搐、心律失常、肝酶升高等。年龄≥60岁的老年患者更易发生ADR(占58%)。结论:临床使用莫西沙星时,应密切关注ADR的发生及危害,加强用药监护,促进莫西沙星安全使用。
Objective: To investigate the characteristics of the adverse drug reaction (ADR) of moxifloxacin and provide the basis for clinical drug safety. Methods: 31 cases of moxifloxacin ADR reported by Beijing Institute of Drug Adverse Reaction Monitoring Center from 2007 to 2009 were analyzed statistically. Results: The incidence of moxifloxacin ADR increased year by year, showing an upward trend. ADR damage system / organ composition ratio followed by anaphylaxis (41.9%), the nervous system (19.4%), the cardiovascular system (16.1%), the digestive system (6.4%) and so on. The main clinical manifestations of rash, visual abnormalities, hallucinations, convulsions, arrhythmia, elevated liver enzymes. Elderly patients older than 60 years of age are more likely to develop ADR (58%). Conclusion: In the clinical use of moxifloxacin, ADR should pay close attention to the occurrence and harm, strengthen the drug custody, and promote the safe use of moxifloxacin.