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目的:了解我肿瘤专科医院药品不良反应(ADR)发生的特点及规律。方法:对我院2009年收集并上报的437例ADR报告,分别从报告人、患者性别及年龄、引发ADR的药品种类、给药途径、ADR涉及器官或系统及临床表现等方面进行统计分析。结果:437例ADR报告中,50～60岁者ADR比例最高,占38.90%;以抗肿瘤药居多,占55.15%;静脉滴注给药方式是引发ADR的主要给药途径,占75.29%;ADR最常见的临床表现为恶心呕吐以及骨髓抑制。结论:应加强化疗监护,优化给药剂量,并重视ADR的监测工作,以减少或避免ADR的重复发生。
Objective: To understand the characteristics and regularity of adverse drug reaction (ADR) in our cancer hospital. Methods: A total of 437 ADR cases collected and reported in our hospital from 2009 to 2009 were analyzed statistically from aspects such as the reporter, patient’s sex and age, the type of drug causing ADR, the route of administration, organ or system and clinical manifestation of ADR. Results: Among the 437 cases of ADR, the proportion of ADR was the highest in 50-60 years old, accounting for 38.90%; the majority of antitumor drugs were in 55.15%; intravenous drip was the main route leading to ADR, accounting for 75.29%; The most common clinical manifestations of ADR are nausea, vomiting and myelosuppression. Conclusion: Chemotherapy monitoring should be strengthened to optimize the dose, and pay attention to the monitoring of ADR in order to reduce or avoid the recurrence of ADR.