【摘 要】
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Dear Editor,rnTonic immobility(TI),also termed“feigning death,”is the ultimate defensive response to inescapable threats.Since some predators do not like to eat dead animals,they stop hunting or eating the completely rigid prey under the impression that i
【机 构】
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Shenzhen Key Laboratory of Neuropsychiatric Modulation and Collaborative Innovation Center for Brain
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Dear Editor,rnTonic immobility(TI),also termed“feigning death,”is the ultimate defensive response to inescapable threats.Since some predators do not like to eat dead animals,they stop hunting or eating the completely rigid prey under the impression that it is dead.Therefore,TI is generally considered to be an anti-predator behavior and is phylo-genetically conserved across many species[1].Recently,several studies have used an expanding black disk(loom-ing stimulus,LS)to mimic the approach of a natural aerial predator.This predator cue induces long-lasting freezing behavior in mice[2-4](Video S1).Our prior study has shown that this freezing response evoked by the LS is mediated by a subcortical pathway from the superior colliculus(SC)to the amygdala[3].Transient optogenetic activation of excitatory SC neurons in mice is enough to reliably induce a persistent freezing response with TI features,including non-flight to shelter,muscle rigidity,and bradycardia[1,3].Therefore,this persistent freezing is a type of TI response.However,the neural mechanisms underlying TI remain unclear.Given that the probability of LS-evoked TI is rather low[2,4],optogenetic activation of the SC was used as a predator cue to evoke TI throughout this study.
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