【摘 要】
：
Endogenously eliminating the hematoma is a favorable strategy in addressing intracerebral hemorrhage(ICH).This study sought to determine the role of retinoid X receptor-α (RXR-α) in the context of hematoma absorption after ICH.Our results showed that phar
【机 构】
：
Department of Neurosurgery,The Second Affiliated Hospital of Zhejiang University School of Medicine,
论文部分内容阅读
Endogenously eliminating the hematoma is a favorable strategy in addressing intracerebral hemorrhage(ICH).This study sought to determine the role of retinoid X receptor-α (RXR-α) in the context of hematoma absorption after ICH.Our results showed that pharmacologically activating RXR-α with bexarotene significantly accelerated hematoma clearance and alleviated neurological dysfunc-tion after ICH.RXR-α was expressed in microglia/macro-phages,neurons,and astrocytes.Mechanistically,bexarotene promoted the nuclear translocation of RXR-α and PPAR-γ,as well as reducing neuroinflammation by modulating microglia/macrophage reprograming from the M1 into the M2 phenotype.Furthermore,all the beneficial effects of RXR-α in ICH were reversed by the PPAR-γ inhibitor GW9662.In conclusion,the pharmacological activation of RXR-α confers robust neuroprotection against ICH by accelerating hematoma clearance and repolarizing microglia/macrophages towards the M2 phenotype through PPAR-γ-related mechanisms.Our data support the notion that RXR-α might be a promising therapeutic target for ICH.
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