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目的 研究“精之助”胶囊对生殖功能尤其是对精子密度、活动力及形态的影响。方法 (1)对 5 0例少精子症及 (或 )弱精子症患者应用“精之助”一个月 ,观察精液指标变化情况 ;(2 )对小白鼠进行药效学实验 ,观察一般情况、产仔情况、睾丸及附睾组织学及超微结构变化等 ;(3)对小白鼠进行急性毒性实验。结果 “精之助”胶囊可显著改善少精子症及 (或 )弱精子症患者精液指标 ,逆转小白鼠睾丸、附睾超微结构病理变化。急性毒性实验证明该中药制剂无毒性。结论 “精之助”胶囊是男性不育的安全、有效的中药制剂
Objective To study the effect of Jingzhizhu capsule on reproductive function, especially sperm density, motility and morphology. Methods (1) A total of 50 patients with oligozoospermia and/or asthenozoospermia were treated for one month to observe changes in semen parameters; (2) Pharmacodynamic experiments were conducted on mice and general conditions were observed. Calving conditions, histology and ultrastructural changes of testis and epididymis, etc.; (3) Acute toxicity experiments on mice. Results “Qingzhizhu” capsule can significantly improve semen quality in patients with oligozoospermia and (or) asthenozoospermia, reversing the ultrastructural changes of testis and epididymis in mice. Acute toxicity test proved that the Chinese medicine preparation is non-toxic. Conclusion “Jingzhizhu” capsule is a safe and effective traditional Chinese medicine preparation for male infertility