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目的探讨宫腔内人工授精(IUI)影响因素与临床妊娠率的关系,以提高IUI治疗的临床效果。方法对252个IUI治疗周期的159例患者的年龄、不孕年限、促排卵方案、人工授精时机、IUI治疗周期数、不孕原因与临床妊娠率的关系进行分析。结果促排卵周期显著提高临床妊娠率(P<0.05);小于等于30岁组临床妊娠率显著高于30以上组(P<0.05);随不孕年限延长临床妊娠率降低、单次排卵前、单次排卵后和双次授精妊娠率无统计学差异;IUI治疗周期数以3个周期为宜、不孕原因与临床妊娠率有关但无统计学差异。结论促排卵方案和年龄是影响临床妊娠率的主要因素。
Objective To investigate the relationship between intrauterine insemination (IUI) and clinical pregnancy rate in order to improve the clinical effect of IUI treatment. Methods The age, duration of infertility, ovulation induction schedule, timing of artificial insemination, number of cycles of IUI treatment, causes of infertility and clinical pregnancy rate were analyzed in 159 patients with 252 IUI cycles. Results Ovarian cycle significantly increased the clinical pregnancy rate (P <0.05). The clinical pregnancy rates of less than or equal to 30 years old group were significantly higher than those of 30 or more groups (P <0.05). The clinical pregnancy rate was decreased with prolonged infertility, Single ovulation and double fertilization pregnancy rate was no significant difference; IUI treatment cycles to three cycles is appropriate, the cause of infertility and clinical pregnancy rate but no statistically significant difference. Conclusions Ovulation schedule and age are the main factors affecting the clinical pregnancy rate.