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环境响应的智能化递药系统可对肿瘤组织特殊生理环境及体外环境变化而发生相应变化,特异地靶向分布于肿瘤组织或在肿瘤组织的特殊生理环境下释放药物,从而可有效改善并提高抗癌药物对肿瘤靶向治疗效果,降低药物毒副作用,已成为近年来肿瘤靶向治疗研究领域的热点之一。本文综述了环境响应的智能化递药系统的靶向机理及其在肿瘤靶向治疗中的应用,以期为新型肿瘤靶向递药系统的开发及其对肿瘤的治疗提供参考。
Environmental response of the intelligent delivery system can change the specific physiological environment of tumor tissue and changes in vitro environment, specifically targeted distribution in the tumor tissue or release of drugs in the special physiological environment of tumor tissue, which can effectively improve and improve Cancer drug targeted therapy effect and reduce the drug side effects, has become one of the hot topics in the field of tumor targeted therapy in recent years. This review summarizes the targeting mechanism of intelligent delivery system for environmental response and its application in tumor targeted therapy in order to provide a reference for the development of novel tumor targeting delivery system and its application in the treatment of cancer.