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目的:探讨缺血预适应在老年脑梗塞患者预防和治疗中的临床疗效。方法:选取我院治疗的老年脑梗塞患者64例,按随机数字表法分组,对照组32例患者予以临床常规治疗,研究组32患者在对照组的基础上予以缺血预适应治疗,治疗6个月,测定并记录两组间美国国立卫生院神经功能缺损评分(NIHSS)、Barthel指数(BI)及生活质量,同时对比患者临床疗效、疾病复发率、死亡率及不良反应的发生情况。结果:对照组治疗有效率为显著低于研究组,差异具有统计学意义(P<0.05)。与对照组比较,研究组治疗后NIHSS积分较低,BI评分较高,差异具有统计学意义(P<0.05);研究组复发率及死亡率均明显低于对照组,差异具有统计学意义(P<0.05)。结论:缺血预适应对老年脑梗塞患者的预防效果显著,可有效提高患者的生活质量,降低死亡率和复发率。
Objective: To investigate the clinical effect of ischemic preconditioning in the prevention and treatment of elderly patients with cerebral infarction. Methods: Sixty-four elderly patients with cerebral infarction who were treated in our hospital were randomly divided into three groups according to the random number table. Thirty-two patients in the control group were given routine clinical treatment. 32 patients in the study group were given ischemic preconditioning on the basis of the control group. The NIHSS, Barthel Index (BI) and quality of life were measured and recorded. The clinical efficacy, disease recurrence rate, mortality and adverse reactions were compared between the two groups. Results: The effective rate of the control group was significantly lower than that of the study group (P <0.05). Compared with the control group, NIHSS score was lower and BI score was higher in the study group after treatment (P <0.05), and the recurrence rate and mortality in the study group were significantly lower than those in the control group P <0.05). Conclusion: The preventive effect of ischemic preconditioning on elderly patients with cerebral infarction is significant, which can effectively improve the quality of life of patients and reduce the mortality and recurrence rate.