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啮齿类颌下腺(SMG)是雄激素的靶器官,在体外大鼠SMG mRNA的转译和产物的电泳分析证实,至少有两种mRNA在大鼠SMG中的含量雄性大于雌性,这些mRNA编码的蛋白称为SMR1和SMR2。SMR1可能是类似促甲状腺激素释放激素的一种小肽前体,其mRNA被发现雄性大鼠SMG内比雌性高1000-2000倍,并且被阉割的雄性大鼠,该mRNA减少,而给予雄激素的雌性大鼠该mRNA
Rodent submandibular gland (SMG) is the androgen target organ. In vitro rat SMG mRNA translation and product electrophoretic analysis confirmed that at least two mRNAs were found to be more abundant in the male rat SMG than in the female, and the protein encoded by these mRNAs SMR1 and SMR2. SMR1 may be a small peptide precursor like thyrotropin releasing hormone whose mRNA was found to be 1000-2000 folds higher in the male rat SMG than in the female and the castrated male rats were reduced in mRNA while androgen was administered Of female rats