【摘 要】
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For patients with COVID-19 caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the damages to multiple organs have been clinically observed.Si
【机 构】
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CAS Key Laboratory of Systems Biology,Shanghai Institute of Biochemistry and Cell Biology,Center for
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For patients with COVID-19 caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the damages to multiple organs have been clinically observed.Since most of current investigations for virus-host interaction are based on cell level,there is an urgent demand to probe tissue-specific features associated with SARS-CoV-2 infection.Based on collected proteomic data-sets from human lung,colon,kidney,liver,and heart,we constructed a virus-receptor network,a virus-interaction network,and a virus-perturbation network.In the tissue-specific networks associated with virus-host crosstalk,both common and different key hubs are revealed in diverse tissues.Ubiquitous hubs in multiple tissues such as BRD4 and RIPK1 would be promising drug tar-gets to rescue multi-organ injury and deal with inflammation.Certain tissue-unique hubs such as REEP5 might mediate specific olfactory dysfunction.The present analysis implies that SARS-CoV-2 could affect multi-targets in diverse host tissues,and the treatment of COVID-19 would be a complex task.
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