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Coronavirus disease 2019(COVID-19)caused by coronavirus SARS-CoV-2 infec-tion has now evolved into a worldwide cri-sis that triggers substantial morbidity and mortality.COVID-19 occurs more fre-quently and has more serious complica-tions in patients with diabetes mellitus,but the underlying mechanisms remain largely elusive.Here,we summarize cur-rent and evolving concepts on the detri-mental effect of hyperglycemia on SARS-CoV-2 infection and consequences,focus-ing on several key mechanisms underly-ing the link between diabetes and COVID-19.A better understanding of the mecha-nisms by which hyperglycemia worsens the prognosis of COVID-19 is critical for reducing the risk of SARS-CoV-2 infection and its associated mortality.