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多数人同意在冠心病的病原学中有二种因素,即动脉粥样硬化形成和血小板血栓形成。然而在过去的30年中,这些因素在冠心病临床表现中所起的作用以及血栓形成在动脉粥样硬化发病机理中的作用并未重点研究。动脉硬化的研究几乎是脂类和脂蛋白代谢方面的研究的同义词;凝血因子在主要的流行病学和临床试验中未被研究;最常用的实验性动脉粥样硬化方法是造成明显的高胆固醇血症。
Most agree that there are two factors in the etiology of coronary heart disease, namely, atherosclerosis and platelet thrombosis. However, in the past 30 years, the role of these factors in the clinical manifestations of coronary heart disease and the role of thrombosis in the pathogenesis of atherosclerosis have not been studied. Studies of atherosclerosis are almost synonymous with research on lipid and lipoprotein metabolism; clotting factors have not been studied in major epidemiological and clinical trials; and the most commonly used experimental atherosclerosis approach is to cause marked hypercholesterolemia Blood disorders.