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最先提取的生长抑素(somatostatin,SS)是下丘脑的一种14肽(SS-14);后来在小肠、下丘脑发现了作用更强的生长抑素-28。1982年Benoint等发现,大鼠下丘脑和胰脏独立存在着SS-28的前12肽段,称SS-28(1-12)。另有两种分子量分别为4400、8000的多肽尚不能用放射免疫法与SS-28(1-12)分开,故也归入一类。这些多肽都是从分子量为14000的前生长抑素(prosomatostatin)来的。1983年Millar等证实,SS-28以具有生理意义的量释入大鼠垂体门脉。作者以5只雄性成年大鼠为一组,在电刺激正中隆起前及刚结束时分别从颈外静脉及垂体门脉取血;用S320抗血清[识别SS-28(1-12)的C末端]以放免方法测定血样提
The first extracted somatostatin (SS), a 14-peptide of the hypothalamus (SS-14), later found a stronger somatostatin in the small intestine and hypothalamus.28 Benoint et al found that in 1982, The first 12 peptides of SS-28 exist independently in rat hypothalamus and pancreas and are called SS-28 (1-12). There are two other molecular weight of 4400,8000 respectively, the polypeptide can not be radioimmunoassay and SS-28 (1-12) separate, it also fall into the category. These peptides are all from 14,000 molecular weight prosomatostatin. In 1983, Millar et al confirmed that SS-28 was released into the rat pituitary portal vein in a physiologically significant amount. The authors used 5 male adult rats as a group to take blood from the external jugular vein and the pituitary portal venous before and immediately after the mid-electrical stimulation. Using S320 antiserum [C End] to determine the blood sample by radioimmunoassay