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冠状动脉痉挛成为缺血性心脏病的病因,不仅表现在变异型心绞痛,而且也表现在不稳定型心绞痛和急性心肌梗塞。冠状动脉痉挛的发病机理尚不明确,但有下面几种学说:植物神经功能异常学说,冠状动脉器质性病变学说,以及血小板功能及前列腺素的学说等。这些主要是基于变异型心绞痛临床表现而推论的。本文参考关于基础方面的研究成果以及有关临床观察的文献,对冠状动脉痉挛的病因加以探讨。植物神经异常学说泰江等对变异型心绞痛患者,给予肾上腺素而诱发冠状动脉痉挛,给予异丙肾上腺素而不诱发冠状动脉痉挛。给予α受体阻滞剂苯苄胺痉挛被抑制,给予β受体阻滞剂心得安痉挛不被抑制。据此认为,冠状动脉痉挛是由于刺激了大冠状动脉中的α受体而引
Coronary artery spasm has become the cause of ischemic heart disease, not only in variant angina, but also in unstable angina and acute myocardial infarction. The pathogenesis of coronary artery spasm is not yet clear, but there are several theories: autonomic dysfunction theory, theory of coronary artery disease, and platelet function and prostaglandin theory. These are mainly inferred based on the clinical manifestations of variant angina pectoris. This article refers to the basic research results and clinical observation of the literature on the etiology of coronary artery spasm to be explored. The abnormality of autonomic theoryTajiangAnd so on patients with variant angina, given epinephrine and induced coronary spasm, given isoproterenol without inducing coronary artery spasm. Given α-blocker benzene benzene amine spasm is inhibited, given β-blockers spasm Anxin is not inhibited. Accordingly, coronary artery spasm is due to stimulate the large coronary artery in the α receptor