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目的：评价国产奥美拉唑对反流性食管炎的疗效。方法：１３１例反流性食管炎病人，男性７５例，女性５６例，年龄５０±ｓ１０ａ。分为３组：Ａ组４８例，用国产奥美拉唑２０ｍｇ，ｐｏ，ｑｄ；Ｂ组４３例，用法莫替丁２０ｍｇ，ｐｏ，ｂｉｄ；Ｃ组４０例，用进口奥美拉唑２０ｍｇ，ｐｏ，ｑｄ，各组分别加多潘立酮１０ｍｇ，ｐｏ，ｔｉｄ。疗程４ｗｋ。结果：总有效率３组分别为９６％，５１％，９５％；内镜下食管炎消失或改善率分别为９１％，４６％，９２％。Ａ组及Ｃ组均无不良反应。表明：国产奥美拉唑疗效明显优于法莫替丁（Ｐ＜０．０１），与进口奥美拉唑无明显差异（Ｐ＞０．０５）。结论：国产奥美拉唑是治疗反流性食管炎的有效药物，且价格较低
Objective: To evaluate the curative effect of domestic omeprazole on reflux esophagitis. Methods: 131 cases of reflux esophagitis patients, 75 males and 56 females, age 50 ± s10a. Divided into three groups: A group of 48 patients with domestic omeprazole 20mg, po, qd; B group of 43 cases, with famotidine 20mg, po, bid; C group of 40 patients with imported omeprazole 20mg, po, qd, each group plus domperidone 10mg, po, tid. Treatment 4wk. Results: The total effective rate was 96%, 51% and 95% respectively in 3 groups. The disappearance or improvement rate of endoscopic esophagitis was 91%, 46% and 92% respectively. There was no adverse reaction in group A and group C. The results showed that the efficacy of domestic omeprazole was significantly better than that of famotidine (P <0.01), and no significant difference was found between omeprazole and imported omeprazole (P> 0.05). Conclusion: Domestic omeprazole is an effective drug for the treatment of reflux esophagitis, and the price is low