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氯芬待因是由双氯芬酸和磷酸可待因组成的复方动物长期灌胃氯芬待因后，１０ｍｇ·ｋｇ－１·ｄ－１组大鼠有９／２０只死亡，５ｍｇ·ｋｇ－１·ｄ－１组大鼠有１／２０只死亡，２ｍｇ·ｋｇ－１·ｄ－１组大鼠未出现死亡。６．４ｍｇ·ｋｇ－１·ｄ－１组狗有２／４只死亡，２ｍｇ·ｋｇ－１·ｄ－１组狗未出现死亡。除２ｍｇ·ｋｇ－１·ｄ－１组大鼠的体重和食量变化不明显外，给药组大鼠和狗的食量和体重都有明显减少（Ｐ＜０．０５）。外观症状主要表现为：拉稀，黑便及便血，四肢无力，走路左右摇摆，有的甚至卧地不起，个别动物因衰竭而死亡。血液生化测定表明，１０ｍｇ·ｋｇ－１·ｄ－１组大鼠的血液总胆固醇含量增高（Ｐ＜０．０５），总蛋白量下降（Ｐ＜０．０５），６．４ｍｇ·ｋｇ－１·ｄ－１组狗的总胆固醇虽也有增高趋势，但无统计意义。病理学损伤主要在肝、肾和消化道，肝组织充血，肝细胞混浊肿胀、空泡及坏死，肾小管细胞浊肿及核消失，肠胀气，部分胃、肠道粘膜脱落坏死，个别严重者出现胸水和腹水。血液学、尿常规、心电图及脏器系数测定结果表明给药组和对照组没有显著性差异。恢复期大鼠和狗的食量和体重都有明显回升，血液生化指标和病理变化也都有好转，说明该药对动物所?
Chlorsulfuron is a compound animal consisting of diclofenac and codeine phosphate. After long-term administration of clofibensine, 9/20 and 10 mg · kg-1 · d-1 rats died, 1/20 rats died in d-1 group, and 2mg · kg-1 · d-1 rats did not die. There were 2/4 deaths in the group of 6.4 mg · kg -1 · d -1 and no death occurred in the 2 mg · kg -1 · d -1 group. The body weight and food intake of rats in 2 mg · kg-1 · d-1 group were significantly decreased (P <0.05). Appearance symptoms mainly as follows: diarrhea, melena and blood in the stool, limb weakness, swaying around, and some even lying on the ground, some animals died of failure. The biochemical analysis of blood showed that the total cholesterol content of 10 mg · kg-1 · d-1 group increased (P <0.05), the total protein decreased (P <0.05), and the level of 6.4 mg · kg-1 · Although the total cholesterol in d-1 group also increased, there was no statistical significance. Pathological damage mainly in the liver, kidney and digestive tract, congestion of liver tissue, hepatocellular swelling, vacuolization and necrosis, tubular cell turbidity and nuclear disappear, flatulence, part of the stomach, intestinal mucosal shedding and necrosis, individual serious Pleural effusion and ascites appear. The results of hematology, urinalysis, electrocardiogram and organ coefficient showed that there was no significant difference between the drug group and the control group. The recovery of rats and dogs have significantly increased food intake and weight, blood biochemical indicators and pathological changes have also improved, indicating that the drug on animals?