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目的:分析慢性阻塞性肺疾病急性发作(AECOPD)患者采用清热化痰法配合低剂量激素进行治疗的疗效。方法:选取100例AECOPD患者,将其随机分成两组:对照组50例给予无创辅助通气、祛痰、抗生素抗菌及支气管扩张剂等常规治疗,同时给予常规剂量激素治疗;观察组50例在对照组患者的治疗基础上,将激素的用量减半,并给予痰热清注射液联合治疗。治疗结束后对两组患者的治疗效果进行评估分析,同时观察两组患者治疗前后的相关指标变化情况。结果:两组患者治疗后总有效率比较,差异无统计学意义(P>0.05);与治疗前相比,两组治疗后的p H值、氧分压(PO2)、二氧化碳分压(PCO2)、肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)等指标均有明显改善(P<0.05);而治疗前后两组的以上指标组间对比,差异无统计学意义(P>0.05)。结论:对AECOPD患者采用清热化痰法配合低剂量激素进行治疗疗效显著,安全性较高。
Objective: To analyze the curative effect of treating patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with the method of clearing away heat and dissipating phlegm and low dose of hormone. Methods: A total of 100 AECOPD patients were selected and divided into two groups at random: control group of 50 patients were given conventional therapy such as noninvasive assisted ventilation, expectorant, antimicrobial antibiotics and bronchodilators, and 50 cases in observation group On the basis of the treatment of patients, the amount of hormones was halved and Tanreqing injection was given. After treatment, the therapeutic effect of the two groups of patients was evaluated and analyzed, and the changes of related indicators before and after treatment were observed in both groups. Results: There was no significant difference in the total effective rate after treatment between the two groups (P> 0.05). Compared with before treatment, p H value, oxygen partial pressure (PO2), partial pressure of carbon dioxide ), Tumor necrosis factor-α (TNF-α) and interleukin-8 (IL-8) were significantly improved (P <0.05). There was no significant difference in the above indexes between the two groups before and after treatment Significance (P> 0.05). Conclusion: The treatment of patients with AECOPD using the method of clearing away heat and dissipating phlegm with low-dose hormone is effective and safe.