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目的评价ABO血型和丙型肝炎病毒感染(HCV)与胰腺癌之间和关系。方法研究回顾753例胰腺癌患者和3012例健康对照的资料,采用多变量回归分析估计校正风险比。结果与O比较,A、AB、B型的校正风险比为1.29(95%CI,1.05~1.58;P=0.01)。乙型肝炎表面抗原阳性与胰腺癌无关,无论是单变量(风险比1.03;95%CI,0.69-1.53;P=0.91)或是多变量分析(校正风险比1.02;95%CI,0.67~1.56;P=0.93)均如此。丙型肝炎病毒抗体阳性时胰腺癌的校正风险为2.30(95%CI,1.30~4.08;P<0.01)。结论本研究结果提示非O血型和抗HCV阳性增加胰腺癌发生风险,而乙型肝炎则否。
Objective To evaluate the relationship between ABO blood group and hepatitis C virus infection (HCV) and pancreatic cancer. METHODS: The data from 753 patients with pancreatic cancer and 3012 healthy controls were reviewed. Multivariable regression analysis was used to estimate the adjusted risk ratio. Results Compared with O, the corrected risk ratio of A, AB, B was 1.29 (95% CI, 1.05-1.58; P = 0.01). Hepatitis B surface antigen positive was not associated with pancreatic cancer, either univariate (hazard ratio 1.03; 95% CI, 0.69-1.53; P = 0.91) or multivariate analysis (adjusted for risk ratio 1.02; 95% CI, 0.67-1.56 ; P = 0.93) both. The adjusted risk for pancreatic cancer with positive Hepatitis C virus antibody was 2.30 (95% CI, 1.30 to 4.08; P <0.01). Conclusion The results of this study suggest that non-O blood group and anti-HCV positive increase the risk of pancreatic cancer, while hepatitis B is not.