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恶性肿瘤的根本特性是侵袭转移,病程晚期可出现多脏器的转移。骨骼是转移的好发部位之一,常见于肺癌、乳腺癌、前列腺癌、结肠癌等肿瘤[1],约20%~30%患者确诊肿瘤时即已存在骨转移[2]。恶性肿瘤骨转移所造成的骨骼变化以溶骨性改变为主,临床可出现骨相关事件如病理性骨折、骨髓压迫等[3],严重影响患者的生活质量,必须迅速有效地预防骨相关事件发生、缓解控制相关症状。双膦酸盐作用于破骨细胞,阻止骨质吸收,是目前治疗骨转移的主要药
The basic characteristics of malignant tumor invasion and metastasis, the late course of multiple organ metastasis may occur. Bone is one of the predilection sites for metastasis, common in lung cancer, breast cancer, prostate cancer, colon cancer and other tumors [1], about 20% to 30% of patients diagnosed with the tumor that bone metastases already exist [2]. Bone metastasis caused by bone metastasis of malignant tumors is dominated by osteolytic changes. Bone-related events such as pathological fractures and bone marrow compression may occur clinically. [3] Seriously affect the quality of life of patients and must promptly and effectively prevent bone-related events Occurrence, ease control related symptoms. Bisphosphonates act on osteoclasts to prevent bone resorption and are the mainstay of treatment for bone metastases