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目的:优化养正消积胶囊浸膏真空带式干燥的工艺参数。方法:采用HPLC-ELSD测定齐墩果酸含量,流动相乙腈-甲醇-0.5%乙酸(20∶70∶10)。以干膏含水率和齐墩果酸转移率为评价指标,采用正交试验考察进料速度、履带速度、加热系统温度对养正消积胶囊浸膏真空带式干燥工艺的影响。结果:最佳带式干燥工艺条件为履带速度6 cm·min-1,进料速度12 mL·min-1,干燥温度110℃,物料温度30℃,冷却区温度45℃,浸膏初始含固量约45%,真空度<-0.1 MPa;干膏含水率2.62%,RSD 1.2%;齐墩果酸转移率95.4%,RSD 0.42%。结论:优选的真空带式干燥工艺合理可行,干膏含水率低,质量好,适合养正消积胶囊的大生产推广。
Objective: To optimize the process parameters of vacuum belt drying of Yangzheng Xiaoji capsule extract. Methods: Oleanolic acid was determined by HPLC-ELSD. The mobile phase was acetonitrile-methanol-0.5% acetic acid (20:70:10). Taking the moisture content of dry matter and the oleanolic acid transfer rate as evaluation indexes, the effects of feed speed, crawler speed and heating system temperature on the vacuum belt drying process of Yangzheng Xiaojian capsules were investigated by orthogonal test. Results: The optimum conditions of belt drying were as follows: the crawler speed was 6 cm · min-1; the feed speed was 12 mL · min-1; the drying temperature was 110 ℃; the temperature of the material was 30 ℃; the temperature of the cooling zone was 45 ℃; About 45%, vacuum <-0.1 MPa; 2.62% moisture content of dry cream, RSD 1.2%; oleanolic acid transfer rate of 95.4%, RSD 0.42%. Conclusion: The preferred vacuum belt drying process is reasonable and feasible, low moisture content of dry paste, good quality, suitable for Yangzheng Xiaoji capsule large-scale production promotion.