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目的 分析双环醇治疗乙型肝炎病毒(HBv)再激活后肝功能异常的临床效果.方法 选取中国人民解放军153中心医院收治的HBV再激活后肝功能异常患者88例,采取数字随机法,随机分成观察组(n=44)和对照组(n=44),两组均停止使用抗结核药物,对照组给予常规治疗,观察组在常规治疗基础上,加用双环醇治疗,比较两组临床效果及安全性.结果 两组患者治疗后2、4周ALT水平均低于治疗前,差异均有统计学意义(P＜0.05).两组患者治疗后4周ALT水平均低于治疗后2周,差异均有统计学意义(P＜0.05).观察组治疗后2、4周ALT水平均低于对照组,差异均有统计学意义(P＜0.05).两组患者治疗后ALB、AST、TBIL水平均高于治疗前,差异均有统计学意义(P＜0.05).观察组患者治疗后ALB水平高于对照组,AST、TBIL水平低于对照组,差异均有统计学意义(P＜0.05).观察组患者治疗2、4周后ALT恢复至正常率高于对照组,差异有统计学意义(P＜0.05).两组不良反应发生率均为0.00％,两组不良反应发生率比较,差异无统计学意义(P＞0.05).结论 双环醇治疗HBV再激活后肝功能异常的临床效果显著,并且较为安全,是可行性较高的治疗方法之一.“,”Objective To analyze clinical effect of bicyclol treatment of hepatitis b virus (HBV) reactivation of abnormal liver function.Methods Our hospital after HBV reactivation in patients with abnormal liver function of 88 cases,adopt digital random method,randomly divided into observation group (n =44) and control group (n =44),two groups have stopped using anti-TB drugs,the control group given conventional treatment,observation group on the basis of conventional treatment,and treatment with bicyclol,comparing two groups clinical efficacy,and safety.Results Two groups of 2,4 weeks after treatment in patients with ALT levels are lower than before treatment,differences were statistically significant (P ＜ 0.05).ALT level 4 weeks after treatment in both groups were less than 2 weeks after treatment,the differences were statistically significant (P ＜ 0.05).Observation group 2,4 weeks after treatment the ALT levels are lower than that of the control group,the differences were statistically significant (P ＜ 0.05).Propagated after treatment in both groups,AST,TBIL level are higher than that of before treatment,the differences were statistically significant (P ＜0.05).Observation group of patients after treatment propagated level higher than the control group,AST,TBIL level lower than that of the control group,the difference had statistical significance (P ＜ 0.05).Observation group of patients after treatment of 2,4 weeks ALT back to normal level is higher than the control group,the difference was statistically significant (P ＜ 0.05).Incidence of adverse reactions of the two groups were 0.00％,two groups compare the incidence of adverse reactions,there was no statistically significant difference (P ＞ 0.05).Conclusion Bicyclol treatment HBV reactivation of abnormal liver function clinical effect after is remarkable,and safer,which is one of the treatment of high feasibility.